27th March 2017 Kym Jacks-Bryant

A+E visits

Data from the IMPRESS study 2,3

A retrospective, observational, multicentre study including 145 patients from 11 UK NHS centres. Conducted from Aug 2014 to Jun 2015.
AIM: To compare resource use in the 6 and 12 months before and after rifaximin- α initiation in UK patients with HE.
This study was sponsored by Norgine.
Mean number of emergency department visits 3 All-cause visits

Safety

  • 4% patients (9/145) reported adverse drug reactions(ADRs)
  • 4/9 of these patients had C difficile infection and none discontinued treatment
  • No serious ADRs were reported
UK/XIF5/0719/0523  DOP: October 2019

Norgine Pharmaceuticals Limited. Norgine House, Widewater Place, Moorhall Road, Uxbridge, Middlesex, UB9 6NS. Company number 03527131.

01895 826600
http://norgine.co.uk/

© Copyright Norgine 2019
Policies

Footer smpc link
TARGAXAN smpc

Product under licence from Alfasigma S.p.A. TARGAXAN is a registered trademark of the Alfasigma group of companies, licensed to the Norgine group of companies.

NORGINE and the sail logo are registered trademarks of the Norgine group of companies.
Zerif Lite Developed by ThemeIsle

References

  1. Orr J G, Currie C J et al. Liver Int 2016;36:1295-1303
  2. Hudson M, et al. Frontline Gastroenterology. Published Online First: 07-April-2017. doi:10.1136/flgastro-2016-100792
  3. Hudson M, et al. Frontline Gastroenterology. Published Online First: 07-April-2017. doi:10.1136/flgastro-2016-100792 Supplementary Material
A retrospective, observational, multicentre study including 145 patients from 11 UK NHS centres. Conducted from Aug 2014 to Jun 2015.
AIM: To compare resource use in the 6 and 12 months before and after rifaximin-α initiation in UK patients with HE.
INCLUSION CRITERIA: Clinical diagnosis of HE. HE diagnosed prior to rifaximin-α initiation. Initiated on rifaximin-α at least 12 months prior data collection.
EXCLUSION CRITERIA: Rifaximin-α initiated at other hospitals. Medical records unavailable.

Details of hospitalisations and hospital visits were extracted from NHS Trust electronic databases. Analysis included only alive patients at the end of 6 and 12 month periods.
IMPRESS study was sponsored and funded by Norgine

Rifaximin-α initiation dose was 1100mg/day (licensed dose) in 30%, 1200 mg/day in 64%, and other doses in 6% of patients, respectively.
This study included patients started on rifaximin-a prior to the launch of TARGAXAN® 550mg bd. 82% of patients (n=119) were taking concomitant lactulose at baseline.